My Editor’s Choice

Promoting Education and Attainment of the Highest Level of Knowledge and Understanding of Clinical Neurophysiology

The International Federation of Clinical Neurophysiology (IFCN) has member societies in 62 countries. The IFCN mission is to promote best practice in clinical neurophysiology through education and research throughout the world. And our vision is to improve healthcare worldwide by understanding the nervous system and optimizing the diagnosis and treatment of its disorders through clinical neurophysiology.

Professor Ulf Ziemann
Editor-in-Chief, Clinical Neurophysiology

The Editor’s Choice for CLINPH Vol 130 Issue 3 (March 2019) is now online:

Olesen SS, Jackson CD, Gram M, Zacharias HD, Dirks M, Weissenborn K, Drewes AM, Morgan MY (2019) Cortical networks are disturbed in people with cirrhosis even in the absence of neuropsychometric impairment. Clin Neurophysiol 130:419-427

Hepatic encephalopathy ranging from mild decrease in intellectual ability and coordination to confusion, gross disorientation and altered consciousness is a common sequelae of liver cirrhosis. Typical abnormalities in conventional EEG assessment are triphasic waves and increase of delta power. This work by Olesen and colleagues goes one step ahead by application of advanced resting-state EEG analysis using the phase-lag index to examine functional connectivity in a large cohort of 264 patients with cirrhosis compared to 98 healthy controls (reference). Analyses were stratified by EEG frequency bands and psychometric data. They found that functional connectivity in cirrhosis was increased in the theta-band and decreased in delta-, alpha- and beta-bands. The alterations in the theta- and alpha-bands were already significant in psychometrically normal patients. Data were replicated in a validation cohort of another 106 patients. The findings suggest that functional connectivity analysis of EEG data can detect subclinical /preclinical hepatic encephalopathy in cirrhosis, and may serve as a surrogate marker for monitoring treatment effects. This important prospective will have to be tested further in longitudinal clinical trials.

Figure. Average head maps showing the spatial distribution of functional connectivity estimates in the discovery cohort, by neuropsychometric performance, stratified by the Psychometric Hepatic Encephalopathy Score (PHES). The raw PHES data were adjusted and scored using UK normative values; a PHES score < 2 is considered abnormal using conventional thresholds.

The paper can be downloaded by just one click from the following link:

Read editor’s choice collection of articles:

Cortical networks are disturbed in people with cirrhosis even in the absence of neuropsychometric impairment
2019 March Vol. 130, Issue 3

Interictal spike connectivity in human epileptic neocortex
2019 February Vol. 130, Issue 2

Recommendations of the International Society of Intraoperative Neurophysiology for intraoperative somatosensory evoked potentials
2019 January Vol. 130, Issue 1

Indications for neuromuscular ultrasound: Expert opinion and review of the literature

2018 December Vol. 129, Issue 12

Decreasing subthalamic deep brain stimulation frequency reverses cognitive interference during gait initiation in Parkinson’s disease
2018 November Vol. 129, Issue 11

Fasciculation intensity and disease progression in amyotrophic lateral sclerosis
2018 October Vol. 129, Issue 10

Multi-component intrinsic brain activities as a safe alternative to cortical stimulation for sensori-motor mapping in neurosurgery
2018 September Vol. 129, Issue 9

Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres
2018 August Vol. 129, Issue 8

Decrease of motor cortex excitability following exposure to a 20 Hz magnetic field as generated by a rotating permanent magnet
2018 July Vol. 129, Issue 7

Phantom somatosensory evoked potentials following selective intraneural electrical stimulation in two amputees
2018 June Vol. 129, Issue 6

Clinical utility of EEG in diagnosing and monitoring epilepsy in adults
2018 May Vol. 129, Issue 5

Vestibulo-cochlear function in inflammatory neuropathies
2018 April Vol. 129, Issue 4

Sleep patterns associated with the severity of impairment in a large cohort of patients with chronic disorders of consciousness
2018 March Vol. 129, Issue 3

Somatosensory Evoked Potentials and Central Motor Conduction Times in children with dystonia and their correlation with outcomes from Deep Brain Stimulation of the Globus pallidus internus
2018 February Vol. 129, Issue 2

Abnormal functional connectivity of high-frequency rhythms in drug-naïve schizophrenia
2018 January Vol. 129, Issue 1

Ear-EEG detects ictal and interictal abnormalities in focal and generalized epilepsy – A comparison with scalp EEG monitoring
2017 December Vol. 128 Issue 12

Long term correlation of subthalamic beta band activity with motor impairment in patients with Parkinson’s disease
2017 November Vol. 128 Issue 11

The standardized EEG electrode array of the IFCN
2017 October Vol. 128 Issue 10

Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines
2017 September Vol. 128 Issue 9

Reduced electrode arrays for the automated detection of rhythmic and periodic patterns in the intensive care unit: Frequently tried, frequently failed?
2017 August Vol. 128 Issue 8

A novel methodology for assessing laryngeal and vagus nerve integrity in patients under general anesthesia
2017 July Vol. 128 Issue 7

The evolution of motor cortical dysfunction in amyotrophic lateral sclerosis
2017 June Vol. 128 Issue 6

Parietomotor connectivity in the contralesional hemisphere after stroke: A paired-pulse TMS study
2017 May Vol. 128 Issue 5

Early disturbances in multimodal evoked potentials as a prognostic factor for long-term disability in relapsing-remitting multiple sclerosis patients
2017 April Vol. 128 Issue 4

Pain perception in patients with chronic disorders of consciousness: What can limbic system tell us?
2017 March Vol. 128 Issue 3

TMS combined with EEG in genetic generalized epilepsy: A phase II diagnostic accuracy study
2017 February Vol. 128 Issue 2

Haemodialysis alters peripheral nerve morphology in end-stage kidney disease
2017 January Vol. 128 Issue 1

The significance of ultrasonographic carpal tunnel outlet measurements in the diagnosis of carpal tunnel syndrome
2016 December Vol. 127 Issue 12

Motor cortical dysfunction develops in spinocerebellar ataxia type 3
2016 November Vol. 127 Issue 11

Intraoperative spinal cord monitoring using low intensity transcranial stimulation to remove post-activation depression of the H-reflex
2016 October Vol. 127 Issue 10

The relationship between seizures, interictal spikes and antiepileptic drugs
2016 September Vol. 127 Issue 9

Disease-specific sparing of the anterior semicircular canals in bilateral vestibulopathy
2016 August Vol. 127 Issue 8

Brain areas with epileptic high frequency oscillations are functionally isolated in MEG virtual electrode networks
2016 July Vol. 127 Issue 7

Cortical correlates of susceptibility to upper limb freezing in Parkinson’s disease
2016 June Vol. 127 Issue 6

Normal pressure hydrocephalus: Increase of utricular input in responders to spinal tap test
2016 May Vol. 127 Issue 5

Ascending vestibular drive is asymmetrically distributed to the inferior oblique motoneuron pools in a subset of hemispheric stroke survivors
2016 April Vol. 127 Issue 4

Language mapping using high gamma electrocorticography, fMRI, and TMS versus electrocortical stimulation
2016 March Vol. 127 Issue 3

Short pauses in thalamic deep brain stimulation promote tremor and neuronal bursting
2016 February Vol. 127 Issue 2

Yield of MRI, high-density electric source imaging (HD-ESI), SPECT and PET in epilepsy surgery candidates
2016 January Vol. 127 Issue 1

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