Clinical Neurophysiology Journal - Editor's Choice

Professor Robert Chen,Editor-in-Chief, Clinical Neurophysiology

Professor Robert Chen
Editor-in-Chief, Clinical Neurophysiology

The Editor’s Choice—

Trait-dependent effects of theta burst stimulation after psychosocial stress: a sham-controlled study in healthy individuals

Clinical Neurophysiology Volume 162 (June 2024)

Stefanie De Smet, Isabell Int-Veen, Gert Vanhollebeke, Matias M. Pulopulos, Beatrix Barth, Sarah Pasche, Chris Baeken, Hans-Christoph Nuerk, Christian Plewnia , Vanessa Nieratschker, Andreas Jochen Fallgatter, Ann-Christine Ehlis, Marie-Anne Vanderhasselt, David Rosenbaum

Repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (DLPFC) is an approved treatment for medication resistant depression. rTMS administered as theta burst stimulation (TBS) has the advantage of shorter treatment time compared to conventional high frequency rTMS. Rumination, which refers to negative thinking often triggered by stressful events, is related to increased psychological stress response and can negatively impact mental and physical health. In this volume of Clinical Neurophysiology, De Smet et al. reported the results of a large, sham controlled trial of continuous TBS (cTBS) and intermittent TBS of the left DLPFC on stress-reactive rumination and the associated psychophysiological stress response. The study showed that cTBS reduced certain measures of stress. Importantly, cTBS induced attenuation of stress-induced cortisol response was more pronounced in high compared to low trait ruminators. It is widely acknowledged that there is considerable between subject variability in the response to treatment of neurological and psychiatric disorders using non-invasive brain stimulation. These results emphasized that the importance of personalized treatment as baseline individual differences can predict the treatment response.

Editor Choice- Highlights (June 2024)

Read editor’s choice collection of articles: